For reasons that are unclear, affected people with neurological symptoms are more likely to have distinctive facial features than those without neurological symptoms. Affected individuals may also have distinctive facial features such as a long face, outside corners of the eyes that point downward (down-slanting palpebral fissures), a low nasal bridge with wide nostrils, and an open-mouth expression. Some people with Proteus syndrome have neurological abnormalities, including intellectual disability, seizures, and vision loss. Blood vessels (vascular tissue) and fat (adipose tissue) can also grow abnormally in Proteus syndrome.
PROTEUS SYNDROME SKELETON SKIN
This type of skin growth usually occurs on the soles of the feet and is hardly ever seen in conditions other than Proteus syndrome. The condition can also cause a variety of skin growths, particularly a thick, raised, and deeply grooved lesion known as a cerebriform connective tissue nevus. Bones in the limbs, skull, and spine are often affected. In people with Proteus syndrome, the pattern of overgrowth varies greatly but can affect almost any part of the body. It is associated with a range of tumors, pulmonary complications, and a striking predisposition to deep vein thrombosis and pulmonary embolism. Overgrowth becomes apparent and progresses rapidly between the ages of 6 and 18 months and gets more severe with age, causing severe overgrowth and disfigurement. Newborns with Proteus syndrome have few or no signs of the condition. The overgrowth is usually asymmetric, which means it affects the right and left sides of the body differently. Organs and tissues affected by Proteus syndrome grow out of proportion to the rest of the body.
Proteus syndrome is a rare condition characterized by progressive overgrowth of the bones, skin, adipose tissue and central nervous system 1).